Louie's father throws a wrench into Casey and Dawson's family plans. Severide agrees to a bone marrow donation but a work accident throws everything into flux. Casey and Dawson try to find harmony at home. Meanwhile, Otis and Mouch decide to film a PSA encouraging people to join the Chicago Fire Department but hit a creative wall in the process.
Dawson tries to keep her emotions in check during an ambo run involving a pregnant teenager, while Casey is forced to make a split-second decision regarding two victims in need of assistance and deal with the repercussions.
When similar car accidents uncover the fact that someone may be targeting innocent people, a determined Dawson takes matters into her own hands to help push things along, meanwhile Casey tends to his Alderman's duties.
Lt. Casey butts heads with the new chief who fills in for Boden at House 51; Mullins has an unexpected surprise for Casey when he makes a risky move to stop a man from jumping off the building; Brett learns information about a friend.
While running a secret errand, Dawson finds herself trapped in a collapsed parking structure; pressure mounts on Casey as he begins taking on additional duties; Kidd grows increasingly skeptical of Hope.
Casey and Severide find themselves at odds after Casey argues with him over the best way to save a teenager entangled in barbed wire. When Casey looks to Boden for help smoothing out the situation, he comes to the realization that he will have to fix it himself. Elsewhere, Otis tries to convince Casey to participate in the beta test for an expensive piece of new firefighting equipment imported from Japan. Meanwhile, Kidd and Hope come to blows over a payroll issue and Brett goes on a date with a doctor she meets during an ambo call.
Kidd is surprised to discover she is being transferred out of the firehouse; Severide and Casey are suspicious and investigate; Otis and Herrmann discuss taking over a rundown bar; Dawson's frustration with her father reaches a boiling point.